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High levels of DNA damage in nerve cells can lead to dementia
Scientists from the world-leading Sheffield Institute for Translational Neuroscience (SITraN) have discovered a novel pathway contributing to dementia in individuals that lack the typical signs of Alzheimer's disease in the brain.
This population-based study shows that one in five of the elderly with documented dementia lack significant amounts of the classical hallmarks of Alzheimer's disease in the brain, namely ß-amyloid plaques and neurofibrillary tangles.
